Is Conolidine An Opiate?

Companies derive opiates from the Poppy Plant. Conolidine is an Analgesic alkaloid much like an opiate but does not come from the Poppy Plant. Does this mean that Conolidine is an opiate?

You can find the Conolidine compound in the Crepe Jasmine plant. It is an analgesic alkaloid that is non-addictive and does not act directly on the GCP receptors like opiates. The literal definition of an opiate is: being derived from or relating to opium. Opium is derived from a singular plant called Papaver Somniferum, or Opium Poppy.

So, without a doubt, Conolidine is not an opiate as it is not derived from the Opium Poppy.

Treating severe and chronic pain is a very hot-button topic. Scientists, practitioners, and consumers seek natural compounds to treat pain. They don’t want them to have the possible nasty side effects generally associated with opiates. This is why, today, we will be delving into this.

The current state of The Opioid Crisis in the United States is a sad yet perfect example of these proposed negative effects. Opiates are generally very habit-forming. We see plenty of effects as a result of addiction. The effects of increasing addiction treatment overdoses and even deaths are scary.

So, is Conolidine an Opiate?

Conolidine is one of the compounds that some suggest concerning safer methods of treating pain. Ideally, we can treat acute, chronic, breakthrough, and moderate pain with a drug or compound that is non-habit forming. This compound is not an opioid.

In addition, it should not put the patient at risk for overdose and should be generally regarded as safe (GRAS). 

This alkaloid, extracted from the Crepe jasmine plant, may not be opiates, but they interact with the chemistry that accompanies pain and pain relief. While opiates work directly on opiate receptors like GCPRs, CONOCB2 is more complex.

Working on opioid peptides, this compound has been found to assist in the regulation of pain signals naturally. Additionally, discovering a pain receptor known as ACKR3/CXCR7 has shown an affinity for this pain-relieving alkaloid. This means that it can potentially assist in alleviating pain the same way as an opiate might. The natural analgesic derived from plant species does this without triggering other chemical signals that can increase issues like addiction and dependency.

In summation, no, Conolidine is not an opiate. This compound may be a fantastic Replacement for opiates. The only correlation is that both relieve pain, as we currently understand it on a neurological level.