Since ancient times, there have been several pharmacologic and non-pharmacologic treatments available for managing chronic pain. Physiologists have been using various cures and medicines for curing pain experienced by people in different body parts but with certain low-level and lethal side effects. The most common of these treatments are:
Non‑Steroidal Drugs With Anti‑Inflammatory Properties
Non-steroidal anti-inflammatory drugs (NSAIDs) offer potent pain relief, anti-inflammatory and fever-reducing properties. They function by hindering cyclooxygenase (COX) enzymes COX-1 and COX-2, which hampers the production of prostanoids. Despite their generally acceptable safety and tolerance, NSAIDs’ usage is restricted due to their side effects. With prolonged use or higher doses, adverse side effects like gastrointestinal ulcers and bleeding, renal issues, coronary heart problems, and thrombotic cardiovascular occurrences take place.
Opioids are very commonly used for overcoming chronic pain by utilizing their opioid receptor-activating properties on nerve cells. Although these can effectively manage moderate to severe acute pain, their utilization for managing chronic pain is limited due to high patient drop-out rates. Moreover, the use of opioids rarely provides long-term pain relief for patients with chronic non-cancerous pain (CNCP) and is associated with common side effects and risks like sedation, dizziness, respiratory depression, constipation, nausea, vomiting, tolerance, physical dependence, hyperalgesia and addiction.
Transdermal Analgesics For Topical Use
To help stay away from oral analgesic agents and their side effects, transdermal analgesic agents like capsaicin and lidocaine have become popular among users. These topical drugs penetrate the skin via passive diffusion exerting analgesic effects. Thus, systemic adverse effects are reduced. However, there is always a risk of skin issues associated with their application. Users have experienced irritation, burning, erythema and skin discoloration.
Yet another category of drugs used for reducing epileptic fits and convulsions, anticonvulsants are also commonly utilized to manage various chronic pain conditions. Drugs like gabapentin, pregabalin and mirogabalin exert their analgesic effects for pain relief but may cause sedation, respiratory depression and altered cognition.
Commonly used antidepressants have exhibited analgesic properties and are effective in pain management due to various neuropathic conditions. The analgesic effects of antidepressants occur at lower doses and this method of treating pain with antidepressants is limited due to their varying side-effect profiles such as dry mouth, dizziness, sedation, constipation, urinary retention, orthostatic hypotension, hypertension and cardiac conduction abnormalities.
Interventional Pain Management
Interventional procedures such as epidural steroid injections, radiofrequency ablation, sympathetic nerve blocks and trigger point injections are relied upon for interventional therapies. These are believed to have more effectiveness as compared to topical or oral analgesic agents. These vary in complexity and invasiveness and might have certain risks associated such as infection, dural puncture, spinal cord trauma and nerve injury.
Transcutaneous Electrical Nerve Stimulation
Transcutaneous electrical nerve stimulation (TENS) is a non-invasive therapy that involves the use of a surface-applied unit that delivers a low-voltage electrical current through the skin to produce analgesia and alleviate pain. The electrical impulses generated via electrodes placed on the skin can help reduce pain signals reaching the brain. Although TENS may stimulate the production of endorphins, the body’s natural painkillers and is generally safe to use, there is insufficient evidence to support its efficacy in chronic pain management.
Conolidine Conocb2 and Other Natural Pain Relief Supplements
Scientists and researchers from all over the world are running tests and laboratory synthesis on a rare natural product called Conolidine. Conolidine is extracted from the bark of the tropical flowering shrub Tabernaemontana divaricata, also known as the pinwheel flower. It is called so due to its shape which resembles a wheel. The plant commonly grows in Southeast Asia, where it has long been used in traditional Chinese, Ayurvedic and Thai medicines for pain and fever. This extract is separated from the bark of the plant and has been widely employed in traditional medicine since ancient times. The latest research may form the basis for developing an effective alternative to prescription medicines for pain treatment. It has been called nature’s morphine Conolidine by some researchers due to its significant pain relief properties with very few side effects.
The rare magical herb – Tabernaemontana divaricata
Conolidine is a rare natural product that can be extracted in large quantities from the plant using chemical means. Synthetic Conolidine conocb2 can be a very effective analgesic with results comparable to those of morphine for treating acute pain and inflammation without any side effects. Not just an effective Natural pain killer for back pain, the other parts of the plants are also used in various medicines. The extract from the leaves is used as an anti-inflammatory for wounds. It can be chewed to overcome the severe pain of toothache. Other extracts from the plant have been used in medicines to treat skin diseases and cancer as well.
In recent years, there have been many studies for finding and developing alternative pain relief medicines that come with no side effects. Morphine and other opioid-based medicines have several adverse side effects associated with their use. These can range from minor effects such as nausea and constipation to major undesirable consequences like addiction to medicine and skin diseases.
Conolidine, on the other hand, belongs to a larger class of natural pain killer for back pain and various other ailments. In recent years, studies initiated by scientists have revealed various potential therapeutic properties of this rare natural product. The conolidine extract obtained from the pinwheel plant has the ability to suppress acute pain and inflammatory-derived pain. It can pass easily through the blood-brain barrier and remain there for up to four hours after injection. As the compound has shown very few or no side effects in most studies, this aspect is still being examined.
Conolidine alkaloid is a plant alkaloid that was first discovered in the bark and root of the tropical flowering crepe jasmine plant. Alkaloids are organic nitrogen compounds extracted from plants and animals, mainly from the leaves, seeds, roots and fruits. Alkaloids possess certain medicinal properties and have varying physiological on humans.
Nature’s morphine Conolidine alkaloid is now being investigated for its effects on the atypical chemokine receptor (ACK3). It is a potent non-opioid analgesic with no complications associated. Conolidine is the future of chronic pain treatment by utilizing naturally occurring analgesics.