Conolidine is a naturally occurring alkaloid that is found in the Tabernaemontana divaricata or Crepe Jasmine bush.
This question is fast becoming a foreground concern. With so many studies out heralding the potential pain-relieving application of the Conolidine alkaloid, many call the claims into question and assume that this compound is unnatural or illegal.
Fortunately, it is neither of those things. Along with 66 additional alkaloids, Conolidine is entirely natural and only found in the Crepe Jasmine plant. With that said, in most testing and studies, Conolidine has been synthesized via organic chemistry to obtain the optimal concentration to test for effects and ensure the ingredient is free from flaws or contaminants.
This is a common practice in the science world. Additionally, concentrations of the Conolidine alkaloid are small in the Crepe Jasmine plant. The alkaloid is generally only found in the bark and roots of the plant in high concentrations. This can prove troublesome for those looking to use high concentrations of the Conolidine alkaloid as bark on a bush is a small mass compared to the remainder of the plant.
In this case, manufacturers have been known to synthesize and standardize the active ingredient much like they would a vitamin of any kind. This generally leads to safer, less contaminated, and targeted dosing. However, the drawback to this is the synthesization portion, as it requires a significant amount of chemical alteration to isolate and concentrate the alkaloid.
Some companies use the whole plant in highly extracted amounts to achieve a higher concentration of the Conolidine alkaloid, while some choose to synthesize the alkaloid. These methods are natural, but we can all agree that untampered material is the more natural route overall.