The Conolidine alkaloid found in the Crepe Jasmine or Tabernaemontana divaricata plant is fast becoming a point of interest for those seeking alternative treatments for pain. However, if it can treat pain, then does this natural alkaloid have the same side effects for pain relief? Is this alkaloid additive?
With early studies showing that Conolidine may be as potent in relieving pain as leading opiate-based painkillers, it is natural to wonder whether or not the same issues might arise with this “new” alkaloid. We know too well what happens when an addictive, easy-to-get painkiller runs rampant.
Traditionally, though effective, opiate and opioid painkillers have extreme drawbacks. From addiction to side effects as severe as death, people want to know if the Conolidine pain reliever comes with the same risks. The last thing you want to discover is that you have access to a natural and safe painkiller only to find out it has caveats.
Unlike opiate-based painkillers, Conolidine is not itself an opiate that contains pain-relieving alkaloids. This natural analgesic has been studied to show that it works by activating “scavenger” receptors in the brain. This receptor helps to alleviate pain.

So, Is Conolidine Addictive?
This revelation is comforting as opiates work on opioid receptors in the brain that can set off a chain reaction. This chain reaction spews tons of pleasure chemicals like dopamine and oxytocin.
Luckily, with Conolidine, this is not the issue. This natural painkiller alleviates pain without triggering potentially deadly addictive chemicals and behavior.
People are becoming more conscious of this pain medication. It is a comfort to know that non-opioids do not carry the same baggage as more traditional methods.
For now, it’s safe to say that Conolidine is NOT addictive. Based on science, it would appear that this medicine has none of the traditional hallmarks of an addictive substance whatsoever.
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