As with any medications you take, you must wonder, “How Safe is Conolidine?”. This is certainly a topic that we discuss in other articles, but let’s pin down the safety of Conolidine.
As you may know by now, Conolidine is an alkaloid from the Crepe Jasmine plant. The interest in Conolidine exists as a result of studies showing that pain relief effects are similar to Morphine.
This is quite the claim. This should concern everyone about whether or not the side effects of Conolidine are the same as Morphine. It would stand to reason that this is the case as Morphine is comparable to Conolidine.
Fortunately, Conolidine is nothing like Morphine; moreover, it does not act the same way on the brain. Opiates and Opioids work on the GCPRs or G protein-coupled receptors. Conolidine works on a newly discovered receptor known as ACKR3/CXCR7, which regulates opioid peptides in the brain.
What Does This Mean?
Simply put, this means that Morphine and Conolidine do not have the same chemistry channels when they work. This also means that other chemicals don’t activate like dopamine or serotonin when Conolidine works.
This means that with Conolidine, you don’t have to worry about dealing with addiction. The Opioid Crisis in the US shows you how horrible this side effect can be.
It is certainly nice to know that Conolidine is safer than Morphine in this regard and regarding all other opiate-derived painkillers as well.
We can establish better safety with Conolidine when talking about certain side effects, but what about general safety? Speaking on general safety is where Conolidine can be lacking.
Conolidine can only be found in the Tabernaemontana divaricata or Crepe Jasmine plant. Conolidine CAN be synthesized, but it is not done on a large scale yet. This means that only natural, full-spectrum (whole plant) extractions are available to consumers.
Generally, when speaking on extractions, you are in Dietary Supplement territory. Whenever you’re in Dietary Supplement territory, you need to know that not all products are created equal.
Pharmaceuticals require stringent regulation and regular audits; it’s much harder to regulate ALL Supplements. Pills you find at your local corner gas station are like the lottery. They will import, pack and sell almost anything.
Only, you don’t get a prize.
Check the Food and Drug Administration’s website, and you will find tons of examples of companies being prosecuted for adulterants. Adulterants can be anything from cocaine in the product to staph from unsafe manufacturing conditions.
So, How Safe Is Conolidine?
It’s not all bad news. Companies are starting to offer safe alternatives with Conolidine in the product like Winters Biotechnology. The fact of the matter is that you can find safe Conolidine, but you have to do your research.
We know that Conolidine and its parent plant, Crepe Jasmine, are considered safe. We also know that companies synthesize Conolidine, but not in high amounts. This leaves us with the option of doing our homework on secure Dietary Supplement options.
Regardless of how safe the end-use product is, it is nice to know that Conolidine is safer. It is safer when it comes to common side effects from painkillers. The same fears we have about painkillers may not have to be our future.